Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 4503 records
Prolonged Honeymoon Period in a Thai Patient with Adult-Onset Type 1 Diabetes Mellitus.
CASE REPORTS IN ENDOCRINOLOGY - 01 Jan 2021
To describe a usual case of adult-onset T1DM with prolonged honeymoon period for more than 5 years. Repeated mixed meal stimulation tests for a period of 6-12 months together with monitoring pancreatic autoantibodies and laboratory data were followed following the onset of diagnosis. We report a 24-year-old Thai patient with T1DM with sustained remission without antidiabetic medication for more...
Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life.
JOURNAL OF HYPERTENSION - 01 Sep 2021
Within-visit SBP variability is associated with age and SBP, but its long-term clinical significance is unknown. We examined the association between child, adult, and life-time within-visit SBP variability with markers of end-organ damage using data from a 31-year longitudinal study. Within-visit SBP variability was calculated as the standard deviation of three sitting SBP readings among up to ...
Within-visit and between-visit intra-individual blood pressure variability in an unselected adult population from rural China.
JOURNAL OF HYPERTENSION - 01 Jul 2021
To assess the association between the variability of blood pressure (BP) readings within an initial clinic visit, the variability within subsequent visits and the variability between visits over 1 week in a general population. This study included 1401 adult residents, who were not taking antihypertensive drugs, having BP measurements at three visits over 1 week. The difference between maximal a...
How to check whether a blood pressure monitor has been properly validated for accuracy.
JOURNAL OF CLINICAL HYPERTENSION (GREENWICH, CONN.) - 01 Dec 2020
Hypertension guidelines recommend that blood pressure (BP) should be measured using a monitor that has passed validation testing for accuracy. BP monitors that have not undergone rigorous validation testing can still be cleared by regulatory authorities for marketing and sale. This is the situation for most BP monitors worldwide. Thus, consumers (patients, health professionals, procurement offi...
Impact of Catheter Ablation on Cognitive Function in Atrial Fibrillation: A Randomized Control Trial.
JACC. CLINICAL ELECTROPHYSIOLOGY - 10 Apr 2023
Early postoperative cognitive dysfunction (POCD) has been reported following atrial fibrillation (AF) ablation. However, whether POCD is persistent long-term is unknown.The purpose of this study was to determine if AF catheter ablation is associated with persistent cognitive dysfunction at 12-month follow-up.This is a prospective study of 100 patients with symptomatic AF who failed at least 1 a...
Assessment of pericoronary adipose tissue attenuation.
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 21 Mar 2023
Impact of Early Versus Delayed Atrial Fibrillation Catheter Ablation on Atrial Arrhythmia Recurrences.
EUROPEAN HEART JOURNAL - 16 Apr 2023
Catheter ablation is an effective strategy in atrial fibrillation (AF). However, its timing in the course of management remains unclear. The aim of this study was to determine if an early versus delayed AF ablation strategy is associated with differences in arrhythmia outcomes during 12-month follow-up.One hundred patients with symptomatic AF referred to a tertiary centre for management were ra...
Projecting the incidence and costs of major cardiovascular and kidney complications of type 2 diabetes with widespread SGLT2i and GLP-1 RA use: a cost-effectiveness analysis.
DIABETOLOGIA - 01 Apr 2023
Whether sodium-glucose co-transporter 2 inhibitors (SGLT2is) or glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are cost-effective based solely on their cardiovascular and kidney benefits is unknown. We projected the health and economic outcomes due to myocardial infarction (MI), stroke, heart failure (HF) and end-stage kidney disease (ESKD) among people with type 2 diabetes, with and wit...
A systematic review of global autopsy rates in all-cause mortality and young sudden death.
HEART RHYTHM - 01 Apr 2023
Autopsy is the gold standard method for determining cause of death. Young sudden death (SD) is a prototype condition in which autopsy is universally recommended. The aim of this review was to quantify real-world global rates of autopsy in either all-cause death or young SD. A systematic review was conducted. Rates of autopsy in all-cause death and in young SD were determined in each country usi...
Inotropic therapy in patients with advanced heart failure. A clinical consensus statement from the Heart Failure Association of the European Society of Cardiology.
EUROPEAN JOURNAL OF HEART FAILURE - 01 Apr 2023
This clinical consensus statement reviews the use of inotropic support in patients with advanced heart failure. The current guidelines only support use of inotropes in the setting of acute decompensated heart failure with evidence of organ malperfusion or shock. However, inotropic support may be reasonable in other patients with advanced heart failure without acute severe decompensation. The cl...
Mitochondrial damage in a Takotsubo syndrome-like mouse model mediated by activation of β-adrenoceptor-Hippo signaling pathway.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Apr 2023
Takotsubo syndrome (TTS) is characterized by short-term contractile dysfunction with its mechanism undefined. We showed that activation of cardiac Hippo pathway mediates mitochondrial dysfunction and that stimulation of β-adrenoceptors (βAR) activates Hippo pathway. Here, we investigated the role of βAR-Hippo signaling in mediating mitochondrial dysfunction in isoproterenol (Iso)-induced TTS-li...
Declining Recognition of Chest Pain as a Cardiac Symptom Should Act as a Shot in The Arm.
HEART, LUNG & CIRCULATION - 01 Apr 2023
Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor.
SIGNAL TRANSDUCTION AND TARGETED THERAPY - 22 Jul 2022
Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys insulin-producing β-cells in the pancreas. An unmet need in diabetes management, current therapy is focussed on transplantation. While the reprogramming of progenitor cells into functional insulin-producing β-cells has also been proposed this remains controversial and poorly understood. The challenge is determining why def...
Intestinal microbiota regulates diabetes and cancer progression by IL-1β and NOX4 dependent signaling cascades.
CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS - 01 Sep 2022
Diabetes changes the host microbiota, a condition known as dysbiosis. Dysbiosis is an important factor for the pathogenesis of diabetes and colorectal cancer (CRC). We aimed at identifying the microbial signature associated with diabetes and CRC; and identifying the signaling mechanism altered by dysbiosis and leading to CRC progression in diabetes. MKR mice that can spontaneously develop type ...
Factors Contributing to the Change in Overweight/Obesity Prevalence Among Indian Adults: A multivariate decomposition analysis of data from the National Family Health Surveys.
ADVANCES IN THERAPY - 01 Dec 2023
Concerns over the escalating burden of non-communicable diseases call for the redressal of behavioral risk factors like increased body mass index. Most studies have failed to quantify the contribution of socio-demographic characteristics in a linear trend. The present study aims to estimate the current prevalence of overweight and obesity in Indian adults and the contribution of different socio...
Improving traffic-related air pollution estimates by modelling minor road traffic volumes.
ENVIRONMENTAL POLLUTION (BARKING, ESSEX : 1987) - 01 Dec 2023
Accurately estimating annual average daily traffic (AADT) on minor roads is essential for assessing traffic-related air pollution (TRAP) exposure, particularly in areas where most people live. Our study assessed the direct and indirect external validity of three methods used to estimate AADT on minor roads in Melbourne, Australia. We estimated the minor road AADT using a fixed-value approach (a...
Evolution and transmission of antibiotic resistance is driven by Beijing lineage in Vietnam.Mycobacterium tuberculosis
MICROBIOLOGY SPECTRUM - 12 Dec 2023
Drug-resistant tuberculosis (TB) infection is a growing and potent concern, and combating it will be necessary to achieve the WHO's goal of a 95% reduction in TB deaths by 2035. While prior studies have explored the evolution and spread of drug resistance, we still lack a clear understanding of the fitness costs (if any) imposed by resistance-conferring mutations and the role that genetic line...
Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity.
NATURE COMMUNICATIONS - 15 Jan 2024
There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer's disease. The role of amyloid beta 42 (Aβ<sub>42</sub>) in these diverse chronic diseases is obscure. Here we show that adipose tissue releases Aβ<sub>42</sub>, which is increased from adipose tissue of male mice with obesity and is associated with higher plasma Aβ<sub>42</sub>. Inc...
Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes.
THE JOURNAL OF CLINICAL INVESTIGATION - 15 Feb 2023
Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust replication in large-scale genome-wide association studies. To understand the role of DNA methylation, it is important to have the prevailing genomic view to distinguish key sequence elements that influence gene expression. This is particularly challenging for DN because genome-wide methylation patterns are ...
Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms.
CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS - 01 Nov 2022
Sulforaphane has been investigated in human pathologies and preclinical models of airway diseases. To provide further mechanistic insights, we explored L-sulforaphane (LSF) in the ovalbumin (OVA)-induced chronic allergic airways murine model, with key hallmarks of asthma. Histological analysis indicated that LSF prevented or reversed OVA-induced epithelial thickening, collagen deposition, goble...
